Cannabidiolic acid (CBDA) is found in fresh whole plant cannabis. Over time, the substance breaks down through the process of decarboxylation, transforming into CBD. It does this by removing the acid group of the molecule. CBDA is the parent molecule of CBD (1).
CBDA vs. CBD
Both CBD and CBDA have unique health benefits that keep your endocannabinoid system running smoothly. For example, CBDA may not be as effective as CBD for inhibiting breast cancer cell proliferation (6), but it is more effective than CBD as a nausea and vomiting treatment (2).
Health Benefits of CBDA
CBDA may help to inhibit the migration of highly aggressive breast cancer (3). Recent studies show that CBDA has antibacterial (4), anti-oxidant, anti-inflammatory (5) and anti-tumor properties. One study showed CBDA may also have anti-nausea effects.
CBD & Breast Cancer
Ninety percent of deaths from breast cancer is due to metastasis to the bones and lungs. COX-2 is an enzyme that is expressed in 40% of breast cancer cases where metastasis has occurred in the bones and lungs. A study found that CBD slows breast cancer metastasis, preventing it from spreading to other body parts. (6)
- Shuso Takeda, Koichiro Misawa, Ikuo Yamamoto and Kazuhito Watanabe. “Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis.” Drug Metabolism and Disposition. September 2008, 36 (9) 1917-1921.
- S Bolognini; EM Rock; NL Cluny; MG Cascio; CLA Limebeer; M Duncan; CG Stott, FA Javid; LA Parker and RG Pertwee.
“Cannabidiolic acid prevents vomiting in Suncus Murinus and nausea-induced behavior in rats by enhancing 5-HT1A receptor activation.” British Journal of Pharmacology. Oct. 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596650/
- Angelo A. Izzo; Francesca Borrelli; Raffaele Capasso; Vincenzo Di Marzo and
Raphael Mechoulam. “Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.” Trends in Pharmacological Sciences. Sept. 2009.
- Hampson AJ1, Grimaldi M, Lolic M, Wink D, Rosenthal R, Axelrod J. “Neuroprotective antioxidants from marijuana.” Annals of the New York Academy of Science. 2000;899:274-82.
- Cary Leizer, David Ribnicky, Alexander Poulev, Slavik Dushenkov & Ilya Raskin.
“The Composition of Hemp Seed Oil and Its Potential as an Important Source
of Nutrition.” Journal of Nutraceuticals, Functional & Medical Foods Vol. 2(4) 2000
- Ligresti A1, Moriello AS, Starowicz K, Matias I, Pisanti S, De Petrocellis L, Laezza C, Portella G, Bifulco M, Di Marzo V. “Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.”https://www.ncbi.nlm.nih.gov/pubmed/20859676