CBD and the Glucose Metabolism

CBD and the Glucose Metabolism - A Recipe for Weight Loss

Are you tired of the endless battle with those stubborn extra pounds? Have you tried every diet under the sun and still haven't seen the results you desire? Well, it might be time to consider a new ally in your weight loss journey: CBD. Yes, you read that right! CBD, short for cannabidiol, the non-psychoactive compound found in cannabis, has been making waves not only for its anxiety-reducing and pain-relieving properties but also for its potential to boost your metabolism and aid in shedding those unwanted pounds.

But before we explore the magic of CBD for weight management, let's clear up the basics.

Understanding Glucose Metabolism

Before we dive into the incredible ways CBD can assist in weight loss, let's take a quick pit stop at "Glucose Metabolism Central." What is glucose metabolism, you ask? Metabolism refers to the complex biochemical processes that happen within our bodies to convert the food we eat into energy. It's like the body's very own power plant, and how efficiently it operates can influence our weight.  Metabolism can be broadly divided into two categories:

  • Basal Metabolism: This is the energy your body needs to perform its basic functions, like breathing and circulating blood. It accounts for a significant chunk of your daily calorie burn, even when you're at rest.
  • Physical Activity: The energy expended during exercise and physical activities. This part of metabolism is under your control and can be influenced by your activity levels.

When our metabolic engine functions optimally, weight management becomes more achievable. The key player here is insulin, a hormone produced by your pancreas.

The Role of Insulin

Insulin, our body's own sugar traffic cop, regulates how glucose is used and stored. Insulin helps transport glucose from your bloodstream into cells, where it's used for energy. When it's working smoothly, glucose is transformed into energy, and we're all good. But when things go awry, and insulin doesn't do its job properly, that's when the extra pounds start creeping in and it even leads to diabetes. This is where CBD enters the stage, offering a helping hand. Now that we've got glucose metabolism under our belts, let's meet CBD.

CBD: What Is It?

CBD, or Cannabidiol, is a natural compound found in the cannabis plant. But hold up, it's not the one that'll make you high; that's THC's job. CBD isn't the party animal of the cannabis family, it is all about the wellness perks without the mind-altering effects.

In more scientific terms, it's a naturally occurring chemical compound, or cannabinoid, found in the cannabis sativa plant. It's extracted from hemp plants, which are a close relative of marijuana but have way lower THC levels. So, you can use CBD without worrying about a psychedelic trip.

People have been using CBD for centuries, mainly for its potential health benefits. But it's recently become a superstar in the wellness world, showing up in everything from oils and creams to gummies and even coffee.

CBD's Interaction with the Endocannabinoid System

Now, here's where CBD enters the picture. Your body has a marvelous system called the endocannabinoid system (ECS). It's like the control center for various functions, including appetite, metabolism, and even mood. CBD interacts with the ECS, potentially influencing how it operates and maintains balance in your body. This balance, known as homeostasis, is crucial for overall health and can be a game-changer in your weight loss goals.

When CBD steps in, it doesn't directly cause weight loss; It's like a supportive friend helping your ECS do its job better.

Here's How CBD Fits into the Metabolic Equation

  • CBD and Insulin Regulation: One of the key players in glucose metabolism is insulin, a hormone that helps regulate blood sugar levels. Studies suggest that CBD may have a positive impact on insulin production and function, making it a potential aid for individuals struggling with insulin resistance, a common precursor to type 2 diabetes. While it doesn't cure diabetes, it can support insulin function and help manage its side effects, such as pain. By supporting insulin function, CBD could contribute to better glucose utilization and potentially aid weight loss efforts.
  • Appetite Control and Weight Loss: The battle against weight gain often involves the relentless struggle to control cravings and overeating. Here's where CBD steps in. Emerging research proposes that CBD may help regulate appetite by influencing the endocannabinoid system, a network that regulates various bodily functions, including hunger and satiety. By curbing appetite, CBD might make it easier to stick to a calorie-controlled diet, a fundamental aspect of successful weight management.
  • Protecting Vital Organs: Your liver, kidneys, and pancreas play crucial roles in glucose metabolism. CBD offers protection to these vital organs, shielding them from potential harm caused by high blood sugar levels. This protection ensures that your metabolism functions optimally.
  • Metabolic Syndrome and CBD: Metabolic syndrome, a cluster of conditions including insulin resistance, obesity, and inflammation, can be a roadblock on the journey to weight loss. CBD's anti-inflammatory properties and potential impact on insulin sensitivity could be valuable assets in managing metabolic syndrome, addressing the underlying factors that hinder weight loss progress.
  • Combating Chronic Inflammation
  • Chronic inflammation is another culprit in disrupted glucose metabolism. CBD is known for its anti-inflammatory properties, which can help reduce inflammation and support a more efficient metabolism.
  • Supporting Overall Well-Being: Beyond its direct effects on metabolism, CBD has garnered attention for its potential to alleviate stress, anxiety, and chronic pain. These factors can contribute to weight gain or hinder weight loss efforts. By promoting a sense of calm and easing discomfort, CBD can create a favorable environment for sustainable weight loss.

Scientific Support for CBD and Weight Loss

But don't just take our word for it; let's turn to the science. In a study involving 4,700 patients with prediabetes, those using cannabis products, which contain CBD, showed lower fasting insulin scores, indicating reduced insulin resistance.

In animal studies, CBD demonstrated a protective effect on the pancreas. Overweight rats given CBD had healthier pancreases compared to the control group. This protection is crucial, as high blood sugar levels can lead to pancreas damage and worsening diabetes symptoms.

Navigating CBD for Weight Loss

As you consider incorporating CBD into your weight loss journey, keep these points in mind:

  • Consult a healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions or are taking medications.
  • Choose high-quality CBD products as not all CBD products are created equal. Look for reputable brands that provide third-party lab testing results to ensure you're getting a pure and potent product and clear ingredient lists
  • Start with a lower dosage and gradually increase as needed, based on your body's response.
  • CBD is not a magic pill for weight loss. Combine CBD with a Healthy Lifestyle, It works best when combined with a balanced diet and regular exercise.

In Conclusion

While CBD may not be a guaranteed solution for weight loss, it can be a valuable addition to your arsenal in the battle of the bulge. Its potential to support metabolism, reduce anxiety, improve sleep, manage pain, and regulate appetite makes it a versatile tool for those looking to shed pounds and lead a healthier life.

Remember, there are no shortcuts to sustainable weight loss. CBD is a complementary aid that can make your journey smoother and more manageable. So, why not give it a try? Consult with a healthcare professional, choose quality products, and embark on your weight loss journey with the potential benefits of CBD by your side. It might just be the recipe you've been looking for to achieve your weight loss goals.



    1. Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6326553/
    2. Parray, H. A., & Yun, J. W. (2016). Cannabidiol promotes browning in 3T3-L1 adipocytes. Molecular and Cellular Biochemistry, 416(1-2), 131-139. doi:10.1007/s11010-016-2702-5 https://pubmed.ncbi.nlm.nih.gov/27067870/
    3. Hurd, Y. L., Spriggs, S., Alishayev, J., Winkel, G., Gurgov, K., & Kudrich, C. (2019). Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial. American Journal of Psychiatry, 176(11), 911-922. https://pubmed.ncbi.nlm.nih.gov/31109198/
    4. Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. (2018). Cannabinoids and pain: New insights from old molecules. Frontiers in Pharmacology, 9, 1259. https://www.frontiersin.org/articles/10.3389/fphar.2018.01259/full

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Can ECD Impact My Health Exploring the Role of Endocannabinoid Deficiency

Can ECD Impact My Health?

Exploring the Role of Endocannabinoid Deficiency

In the world of health and wellness, we often hear about vitamin deficiencies - like the famous vitamin D deficiency, which can leave us feeling less than our best. But have you ever heard of ECD? No, it's not a typo; it stands for Endocannabinoid Deficiency. Just like other deficiencies, it can have a significant impact on your health and well-being. In this article, we'll take a closer look at what ECD is, how it can affect your health, and how CBD, especially full-spectrum CBD oil, can come to the rescue.

Understanding Endocannabinoid Deficiency (ECD)

Let's break it down into simple terms. To grasp the significance of ECD, let's first understand the endocannabinoid system (ECS). Your body has a remarkable system known as the endocannabinoid system (ECS). Think of it as your internal balancing act. It plays a crucial role in maintaining various physiological functions, from mood regulation to sleep patterns, and even how you perceive pain.

  1. Endocannabinoids: These are naturally occurring compounds in your body, similar in structure to cannabinoids found in the cannabis plant. They include anandamide and 2-arachidonoylglycerol (2-AG).
  2. Receptors: The ECS has two primary receptors, CB1 and CB2, scattered throughout your body, from your brain to your immune cells. These receptors are like locks waiting to be engaged by endocannabinoids.
  3. Enzymes: Enzymes like FAAH (fatty acid amide hydrolase) break down endocannabinoids once they've served their purpose.

Now, Here's Where ECD Comes Into Play:

ECD, put simply, is when your body doesn't produce or regulate enough endocannabinoids (the naturally occurring compounds that interact with the ECS) effectively. This deficiency can disrupt the delicate balance within your body, potentially leading to a range of health issues. To draw a parallel, think of ECD as a Vitamin D deficiency – just as your body needs Vitamin D for various functions, it also needs a healthy ECS for overall well-being.

The Health Implications of ECD

The endocannabinoid system (ECS) is a complex network of receptors, enzymes, and endogenous ligands (endocannabinoids) that play a pivotal role in maintaining the body's homeostasis. When this system is out of balance, as seen in Endocannabinoid Deficiency (ECD), it can have profound implications for one's health.

Neurological Disorders

The ECS is deeply involved in the regulation of various neurological processes, including mood, memory, and pain perception. ECD has been linked to several neurological conditions:

  • Migraines: Research suggests that individuals with migraines might have statistically significant differences in cerebrospinal fluid anandamide levels, indicating a potential ECS dysfunction.
  • Fibromyalgia: This condition, characterized by widespread musculoskeletal pain, is associated with ECD. Patients often experience heightened pain sensitivity, possibly due to an underlying endocannabinoid deficiency.

Gastrointestinal Issues

The ECS plays a role in modulating gastrointestinal (GI) propulsion, secretion, and inflammation. ECD can potentially lead to:

  • Irritable Bowel Syndrome (IBS): A functional disorder affecting GI pain, spasms, and bowel movements. The potential relationship between IBS and the ECS suggests that ECD might play a role in its pathogenesis.

Cardiovascular Concerns

The role of the ECS in cardiovascular health is intricate. For instance:

  • Blood Pressure and Heart Rate: Activation of CB1 receptors can lead to hypotension, while CB2 receptor signaling may offer cardioprotective effects.
  • Acute Coronary Syndrome (ACS): Marijuana use and synthetic cannabinoids have been associated with cardiovascular effects, including an increased risk of ACS.

Mental Health Implications

The ECS's role in mood regulation suggests that ECD might be linked to various mental health disorders:

  • Anxiety and Depression: ECD might exacerbate symptoms of anxiety and depression, given the ECS's involvement in mood regulation.
  • Post-Traumatic Stress Disorder (PTSD): There's evidence of ECS hypofunction in PTSD, suggesting a potential link between ECD and this condition.

Pain Management

ECD can potentially exacerbate chronic pain conditions due to the ECS's role in pain perception. This is evident in conditions like fibromyalgia and migraines, where patients often display heightened pain sensitivity.

Metabolic Implications

The ECS is involved in energy balance and metabolism. ECD might play a role in:

  • Obesity and Metabolic Syndrome: Modulating ECS activity has shown potential therapeutic applications in obesity and metabolic syndrome, although with mixed results.

The health implications of ECD are vast and varied, affecting multiple systems and processes in the body. As research continues, our understanding of ECD and its impact on health will undoubtedly expand, offering new insights and potential therapeutic avenues.

The Benefits of Addressing ECD

Endocannabinoid Deficiency (ECD) is a relatively new concept in the world of medical science, but its implications are vast. Addressing ECD can lead to a myriad of health benefits, enhancing the quality of life for many individuals. Here's a deeper dive into the advantages of addressing this deficiency:

  • Alleviation of Chronic Pain: One of the most significant benefits of addressing ECD is the potential relief from chronic pain. Conditions like migraine, fibromyalgia, and irritable bowel syndrome, which are believed to be linked to ECD, often manifest as chronic pain syndromes. By addressing the underlying endocannabinoid deficiency, patients might experience reduced pain intensity and frequency.
  • Improved Sleep Patterns: Sleep disorders, often associated with conditions like fibromyalgia, might be related to ECD. Addressing this deficiency can lead to better sleep quality and duration, allowing individuals to feel more rested and rejuvenated.
  • Enhanced Mood and Mental Health: The ECS plays a crucial role in mood regulation. Addressing ECD can potentially help in alleviating symptoms of depression, anxiety, and other mood disorders. This can lead to improved mental well-being and a more positive outlook on life.
  • Better Digestive Health: The endocannabinoid system has a role in modulating gastrointestinal propulsion, secretion, and inflammation. Addressing ECD can potentially offer relief to those suffering from conditions like irritable bowel syndrome (IBS), leading to improved digestive health.
  • Reduced Inflammation: Inflammation is a common response to various diseases and conditions. The ECS, particularly the CB2 receptors, has been implicated in attenuating inflammation. Addressing ECD can lead to reduced inflammation, which is beneficial for conditions like cardiovascular diseases, arthritis, and more.
  • Potential Cardiovascular Benefits: The role of endocannabinoids and cannabinoid receptors in cardiovascular health is intricate. Addressing ECD might lead to better cardiovascular health, reducing risks associated with conditions like hypertension and atherosclerosis.
  • Holistic Well-being: Beyond the specific health conditions, addressing ECD can lead to an overall sense of well-being. The ECS is involved in various physiological processes, from mood regulation to pain control. Ensuring its optimal function can lead to a more balanced and harmonious state of health.
  • Neuroprotective Effects: The endocannabinoid system has shown the potential to play a protective role in neurodegenerative disorders. Addressing ECD could potentially slow the progression of conditions like Alzheimer's, Parkinson's, and Multiple Sclerosis. This neuroprotective capacity can lead to improved cognitive function and a delay in the onset of neurodegenerative symptoms.
  • Enhanced Immune Response: The ECS plays a role in modulating the immune system. Addressing ECD can lead to a more balanced immune response, potentially reducing the risk of autoimmune diseases and enhancing the body's ability to fight off infections. This means fewer sick days and a more robust defense against common pathogens.

How Can CBD Help With ECD?

CBD, or cannabidiol, has gained immense popularity in recent years due to its potential therapeutic benefits. When shopping for CBD products, you might come across terms like "full-spectrum," "broad-spectrum," and "CBD isolate." Among these, full-spectrum CBD oil stands out for its holistic approach to harnessing the cannabis plant's benefits. Let's delve deeper into what full-spectrum CBD oil is and why it's unique.

What is full-spectrum CBD oil?

Full-spectrum CBD oil is derived from the cannabis plant and contains all the cannabinoids present in the plant, including CBD (cannabidiol), THC (tetrahydrocannabinol), and many others. Unlike CBD isolates, which contain only CBD, full-spectrum CBD oil retains all the therapeutic compounds of the plant, including essential oils, terpenes, and other cannabinoids.

The "Entourage Effect"

One of the primary reasons full-spectrum CBD oil is believed to be more effective in addressing ECD is due to the "entourage effect." This term refers to the synergistic interaction of all the compounds in cannabis when taken together. In essence, the combined effect of all the cannabinoids, terpenes, flavonoids, and other compounds is greater than the sum of their individual effects.

For instance, while CBD has its therapeutic properties when combined with other cannabinoids and compounds in the Full-Spectrum oil, its efficacy can be enhanced. This synergy can lead to better pain management, mood regulation, and overall ECS support.

Addressing ECD with full-spectrum CBD oil

  • Enhanced Receptor Binding: The ECS consists of receptors like CB1 and CB2. full-spectrum CBD oil, with its array of cannabinoids, can bind to these receptors more effectively than CBD alone, ensuring a more comprehensive modulation of the ECS.
  • Natural Terpenes: Full-spectrum CBD oil contains terpenes, which are aromatic compounds found in many plants, including cannabis. Terpenes not only contribute to the flavor and aroma of CBD oil but also have therapeutic properties of their own. Some terpenes have anti-inflammatory, anti-anxiety, and analgesic properties, which can further support the ECS.
  • Balanced THC Levels: While full-spectrum CBD oil does contain THC, it's usually in very low, non-psychoactive amounts (typically less than 0.3%). This trace amount of THC can enhance the therapeutic effects of CBD without causing a "high."
  • Holistic Approach: By addressing ECD with full-spectrum CBD oil, one adopts a holistic approach to health. Instead of just supplementing with one compound (like in CBD isolates), you're providing your body with a range of beneficial compounds that work in harmony.

Considerations When Choosing full-spectrum CBD oil

  • Legal Status: Always check the legal status of THC in your region, as full-spectrum CBD oil contains trace amounts of this compound.
  • Drug Testing: If you're subject to drug testing, be cautious. Even trace amounts of THC could show up in a drug test.
  • Personal Preference: Some individuals might prefer CBD isolate or broad-spectrum CBD (which contains other cannabinoids but no THC) due to personal preferences or specific health concerns.

Lifestyle Changes to Support ECD

Endocannabinoid Deficiency (ECD) can have profound effects on one's well-being. While treatments like CBD offer promise, lifestyle changes can also play a pivotal role in supporting a healthy endocannabinoid system (ECS). Here are some lifestyle modifications that can potentially bolster the ECS and mitigate the effects of ECD:

  • Diet Matters: Just as a balanced diet is essential for overall health, certain foods can support your endocannabinoid system. Omega-3 fatty acids, found in fish, flaxseeds, and walnuts, are precursors to endocannabinoids. Incorporating them into your diet can support endocannabinoid production. Vegetables like broccoli and Brussels sprouts contain beta-caryophyllene, a dietary cannabinoid that can stimulate CB2 receptors.
  • Stress Management: Chronic stress can impair the ECS. Techniques such as meditation, deep breathing exercises, and journaling can help manage stress and support the ECS.
  • Adequate Sleep: Sleep is crucial for a balanced ECS. Endocannabinoid levels can fluctuate with sleep patterns. Ensuring 7-9 hours of quality sleep can help maintain optimal endocannabinoid levels.
  • Limiting Caffeine: While moderate caffeine can be beneficial, excessive intake can interfere with the ECS. It's advisable to monitor caffeine consumption and limit it if necessary.
  • Regular Exercise: Physical activity is known to stimulate the production of endocannabinoids, enhancing the "runner's high" many people feel after a workout. Whether it's a brisk walk, yoga, or more intense activities like running or cycling, find a routine that suits you.

The Road to Wellness

In the grand scheme of things, endocannabinoid deficiency, or ECD, is an important concept to understand when it comes to your health. Just like any other deficiency, addressing it can lead to significant improvements in your well-being.

If you suspect you might be dealing with ECD and its associated health issues, CBD, especially full-spectrum CBD oil, can be a valuable tool in your wellness toolkit. However, it's crucial to consult with a healthcare professional before starting any new dietary or lifestyle regimen, including CBD.

Remember, your health is a journey, and every step you take towards balance and well-being is a step in the right direction. ECD may be a challenge, but with the right approach and the potential benefits of CBD on your side, you can navigate it with confidence and optimism.



    1. Chye Y, Christensen E, Solowij N, Yücel M. The Endocannabinoid System and Cannabidiol's Promise for the Treatment of Substance Use Disorder. Front Psychiatry. 2019 Feb 19;10:63. doi: 10.3389/fpsyt.2019.00063. PMID: 30837904; PMCID: PMC6390812. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390812/
    2. Rabino M, Mallia S, Castiglioni E, Rovina D, Pompilio G, Gowran A. The Endocannabinoid System and Cannabidiol: Past, Present, and Prospective for Cardiovascular Diseases. Pharmaceuticals (Basel). 2021 Sep 17;14(9):936. doi: 10.3390/ph14090936. PMID: 34577636; PMCID: PMC8472406. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8472406/
    3. Pacher P, Kunos G. Modulating the endocannabinoid system in human health and disease--successes and failures. FEBS J. 2013 May;280(9):1918-43. doi: 10.1111/febs.12260. Epub 2013 Apr 22. PMID: 23551849; PMCID: PMC3684164. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684164/
    4. Meccariello R. Endocannabinoid System in Health and Disease: Current Situation and Future Perspectives. Int J Mol Sci. 2020 May 18;21(10):3549. doi: 10.3390/ijms21103549. PMID: 32443408; PMCID: PMC7278997. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278997/
    5. Russo EB. Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes. Cannabis Cannabinoid Res. 2016 Jul 1;1(1):154-165. doi: 10.1089/can.2016.0009. PMID: 28861491; PMCID: PMC5576607. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576607

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The Synergistic Effect of CBD and Adaptogens

The Synergistic Effect of CBD and Adaptogens for Anxiety and Sleep

In our fast-paced world filled with demands and stress, tranquility is a rare gem. CBD and adaptogens are emerging as allies in seeking inner calm and restful sleep, offering hope amid the chaos.

Explore the synergy of CBD, adaptogens (like medicinal mushrooms and herbs like Ashwagandha), and their potential for holistic well-being. Join us in discovering this exciting trio's benefits.

Understanding CBD and Adaptogens

CBD Unveiled: Nature's Non-Psychoactive Gem

At the heart of the CBD phenomenon lies a non-psychoactive compound derived from the hemp plant. Unlike its cousin THC, CBD doesn't induce a euphoric high. Instead, it interacts with the body's endocannabinoid system, a regulatory network that plays a pivotal role in mood regulation, stress management, and sleep cycles.

Adaptogens Decoded: Nature's Stress-Relieving Allies

Adaptogens are a group of herbs known for helping the body cope with stress. They promote balance and resilience, making them useful in managing the stress of modern life. Popular adaptogens include ashwagandha and Rhodiola, which can help calm frazzled nerves.

The Solo Acts: CBD's Benefits and Adaptogen's Magic

When examined individually, CBD and adaptogens each boast impressive attributes. CBD, with its soothing properties, seeks to quiet the mind and restore equilibrium. On the other hand, Adaptogens wield the power to regulate stress hormones like cortisol, thus fostering a serene internal environment.

The Synergy Unveiled: CBD and Adaptogens

The Power of Synergy: When CBD and Adaptogens Join Forces

CBD and adaptogens work together effectively to address anxiety and sleep issues. CBD interacts with the endocannabinoid system, while adaptogens help balance hormones, providing a holistic wellness solution.

Harmony in Regulation: Endocannabinoid System and Stress Response

Inside your body, there's a special system called the endocannabinoid system, kind of like a boss. This system takes care of lots of things in your body, like how you feel, how you handle stress, and when you go to sleep. When CBD works together with this system, it helps create a more even and healthy inside world.

Balancing Act: Adaptogens' Role in Calm and Serenity

Adaptogens, known for their stress-relieving properties, aid the adrenal glands and control stress hormone production. This results in a calmer and more serene disposition, which is vital in today's fast-paced world.

Amplified Results: CBD's Bioavailability Boost

Studies suggest that the partnership between CBD and adaptogens goes beyond simple cooperation. CBD has been found to enhance the absorption and bioavailability of adaptogens, heightening their impact. This amplification could potentially translate into more robust stress relief and improved sleep quality.

Enhancing Benefits of Medicinal Mushrooms

Beyond Buttons: Medicinal Mushrooms as Adaptogens

Enter the world of medicinal mushrooms: Reishi, Cordyceps, and Lion's Mane. These fungi hold adaptogenic properties that perfectly complement the efforts of CBD and traditional adaptogenic herbs. Together, they form a trinity of tranquility.

Reishi: The Calming Maestro

Reishi often crowned the "queen of mushrooms," is a calming force to be reckoned with. Its tranquil attributes seamlessly align with CBD's capacity to soothe anxious thoughts and promote relaxation.

Cordyceps: Energizing the Day, Relaxing the Night

Cordyceps, known for its energy-boosting capabilities during the day, showcases a dual personality when the sun sets. Its ability to enhance relaxation at night can synergize harmoniously with CBD's sleep-inducing potential.

Lion's Mane: From Mental Clarity to Sleep Serenity

Lion's Mane is a cognitive enhancer known for enhancing mental clarity and focus. It helps quiet an overactive mind, promoting better sleep alongside CBD's sleep support.

Crafting a Natural Solution: CBD, Adaptogens, and You

The Essence of Holistic Well-Being

The true magic of combining CBD and adaptogens lies in their holistic approach. Instead of merely addressing surface-level symptoms, they work in tandem to tackle the root causes of anxiety and sleep disturbances.

Personalizing the Blend: CBD, Adaptogens, and Medicinal Mushrooms

To benefit from this combination, customize it to suit your specific requirements. Integrate CBD, adaptogens, and medicinal mushrooms into your daily routine with awareness of your body's reactions, and seek expert advice when needed.

A Nudge Towards Professional Advice: Wellness in Collaboration

While the synergy of CBD, adaptogens, and medicinal mushrooms holds immense promise, individual reactions can vary. Consulting healthcare experts ensures a personalized strategy that maximizes the potential benefits.

Backed by Research: Studies and Insights

Unveiling the Science: Research on CBD's Effects

The case for CBD's efficacy in reducing anxiety and improving sleep quality gains strength from studies like Shannon et al.'s research in 2019. This foundational evidence sets the stage for its harmonious relationship with adaptogens.

Adaptogens in the Limelight: Studies on Stress and Relaxation

Research conducted by Panossian and Wikman in 2010 has unveiled adaptogens' role in stress modulation, providing empirical validation for their partnership with CBD in promoting relaxation.


In the end, CBD, adaptogens, and medicinal mushrooms offer potential benefits for managing anxiety and promoting better sleep. Their combined effects suggest a promising avenue for enhancing relaxation and sleep quality.

Discover the benefits of CBD, adaptogens, and medicinal mushrooms for anxiety and sleep. These natural remedies can help your body find solace and healing, leading to peaceful nights and serene days. Gain knowledge and let these powerful ingredients guide you on this journey to better well-being.


  1. What is CBD, and how might it aid in reducing anxiety and improving sleep?

Cannabidiol, sometimes CBD, is a natural substance obtained from the hemp plant. It works with the endocannabinoid system of the body to control mood and sleep patterns, perhaps lowering anxiety and enhancing sleep quality.

  1. What are adaptogens, and how do they work alongside CBD?

Adaptogens are herbs that aid the body in adapting to stress. They complement CBD by balancing stress hormones like cortisol, promoting calmness and resilience against anxiety-inducing factors.

  1. Can CBD and adaptogens be taken together?

Yes, CBD and adaptogens can be taken together. In fact, they often enhance each other's effects, creating a synergistic response that offers more comprehensive anxiety relief and improved sleep.

  1. How do medicinal mushrooms fit into this mix?

Medicinal mushrooms like Reishi, Cordyceps, and Lion's Mane possess adaptogenic properties that align with CBD and traditional adaptogens. They contribute to overall relaxation, mental clarity, and sleep support.

  1. Are there studies supporting the use of CBD, adaptogens, and medicinal mushrooms for anxiety and sleep?

Yes, research has shown promising results. Studies like Shannon et al. (2019) highlight CBD's potential for anxiety reduction and improved sleep. Panossian and Wikman (2010) shed light on adaptogens' stress-modulating effects, supporting their synergy with CBD.

Tree of Life Botanicals Products with Lion's Mane:

TOLB Immunity

TOLB Sleep


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  2. Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in anxiety and sleep: a large case series. The Permanente Journal, 23.
  3. Panossian, A., & Wikman, G. (2010). Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals, 3(1), 188-224.
  4. Cho, J. W., & Cho, S. Y. (2019). Herbal medicines for the management of insomnia: An overview. Natural Product Sciences, 25(4), 295-305.
  5. Sarris, J., McIntyre, E., Camfield, D. A., & Plant, C. (2019). A comprehensive review of the efficacy, safety and current state of complementary and alternative medicines in the treatment of anxiety. Expert Review of Neurotherapeutics, 19(10), 785-800.:227-232.27544998, S Furuta, R Kuwahara, E Hiraki, K Ohnuki, S Yasuo, K Shimizu.

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The Impact of Immune Health on Female Health

As a woman, it's important to prioritize immune health. Our immune systems are complex and constantly working to keep us healthy, but sometimes they need a little extra support. In this article, we'll explore the impact of immune health on female health and discuss the benefits of adaptogenic mushrooms for immune support.

The Impact of Immune Health on Female Health

Our immune system plays a critical role in keeping us healthy. It defends against pathogens, including viruses and bacteria, and helps prevent chronic diseases like cancer and autoimmune disorders. A weakened immune system can lead to increased susceptibility to infections, slower healing, and chronic inflammation. In addition, hormonal imbalances can also impact immune function, making women more susceptible to certain diseases and infections.

Several factors can weaken the immune system, including stress, poor nutrition, lack of sleep, and sedentary lifestyles. Additionally, certain medications and medical conditions can also impact immune function.

Fortunately, there are steps you can take to support your immune system and improve overall health.

Boosting Immune Response with Adaptogenic Mushrooms

Adaptogenic mushrooms are a group of medicinal mushrooms that have been shown to have immune-boosting properties. These mushrooms work by regulating the immune system, improving the body's response to stress, and enhancing overall health and wellness.

One of the most well-known adaptogenic mushrooms is Reishi (Ganoderma lucidum). Reishi is rich in polysaccharides and triterpenes, which have been shown to have anti-inflammatory and immune-boosting properties. Reishi has been used in traditional Chinese medicine for centuries to enhance longevity, boost immunity, and improve overall health.

Another popular adaptogenic mushroom is Cordyceps (Cordyceps sinensis). Cordyceps has been used in traditional Chinese medicine for centuries to enhance athletic performance, increase energy levels, and improve overall health. Studies have shown that Cordyceps can improve immune function by increasing white blood cell production and enhancing the body's response to infections.

Other adaptogenic mushrooms that are beneficial for immune health include Chaga (Inonotus obliquus), Lion's Mane (Hericium erinaceus), and Turkey Tail (Trametes versicolor). Each of these mushrooms has unique properties that support immune function and overall health.

Incorporating adaptogenic mushrooms into your diet can be as easy as adding them to your morning coffee or smoothie. Many adaptogenic mushrooms are available in supplement form, making it easy to get the immune-boosting benefits without having to cook with them.

Other Ways to Boost Immune Response

In addition to incorporating adaptogenic mushrooms into your diet, there are several other ways to support immune health:

    1. Eat a balanced diet: A diet rich in fruits, vegetables, whole grains, and lean protein can help provide the nutrients your immune system needs to function properly.
    2. Get enough sleep: Lack of sleep can weaken the immune system, making you more susceptible to infections.
    3. Manage stress: Chronic stress can impact immune function. Finding ways to manage stress, such as meditation, yoga, or deep breathing, can help support immune health.
    4. Exercise regularly: Regular exercise can help improve immune function by reducing inflammation and increasing white blood cell production.
    5. Stay hydrated: Drinking enough water can help flush toxins from the body and support immune function.
    6. Avoid smoking and excessive alcohol consumption: Both smoking and excessive alcohol consumption can weaken the immune system, making you more susceptible to infections.


As women, it's important to prioritize immune health. A healthy immune system is critical for overall health and wellness. Adaptogenic mushrooms, like Reishi and Cordyceps, can be a powerful tool for boosting immune function and improving overall health. Incorporating these mushrooms into your diet, along with lifestyle changes like getting enough sleep, managing stress, and exercising regularly, can help support your immune system and improve your overall health.

It's important to note that while adaptogenic mushrooms can be beneficial for immune health, they should not be used as a replacement for medical treatment. If you have a medical condition or are taking medication, it's important to speak with your healthcare provider before incorporating adaptogenic mushrooms into your diet.

In summary, taking care of your immune health is essential for overall health and wellness. By incorporating adaptogenic mushrooms into your diet, along with other lifestyle changes, you can help support your immune system and improve your overall health. So, go ahead and try adding some Reishi or Cordyceps to your morning coffee or smoothie – or try Tree of Life Immunity™ capsules – your immune system will thank you!


    1. Dai, Y. C., Yang, Z. L., & Cui, B. K. (2009). Species diversity and utilization of medicinal mushrooms and fungi in China (review). International Journal of Medicinal Mushrooms, 11(3), 287-302. doi: 10.1615/IntJMedMushr.v11.i3.10
    2. Kalaras, M. D., Poulas, K., & Karathanos, V. T. (2017). Mushroom polysaccharides: Chemistry and antiobesity, antidiabetes, anticancer, and antibacterial properties in cells, rodents, and humans. Foods, 6(10), 91. doi: 10.3390/foods6100091
    3. Li, T., Li, X., Li, B., Gao, X., Zhang, X., Xu, X., & Zhao, J. (2019). Immunomodulatory effects of polysaccharides isolated from Cordyceps sobolifera on macrophages through the TLR4 pathway. Journal of Ethnopharmacology, 235, 150-158. doi: 10.1016/j.jep.2019.02.019
    4. Mattila, P., Könkö, K., Eurola, M., Pihlava, J. M., Astola, J., Vahteristo, L., . . . Törrönen, R. (2001). Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. Journal of Agricultural and Food Chemistry, 49(5), 2343-2348. doi: 10.1021/jf001525d
    5. Wasser, S. P. (2017). Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and immunomodulatory activities: A review. International Journal of Medicinal Mushrooms, 19(4), 279-317. doi: 10.1615/IntJMedMushrooms.2017024279

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Sleep Disorder Health Effects - Mental Health, Magnesium Augmentation and Tips

Sleep Deprivation and How to Conquer It

Sleep Disorder Health Effects - Mental Health, Magnesium Augmentation and Tips

The Dark Side of Sleep Deprivation: Health Effects and How to Conquer It

Do you feel tired all the time? Do you have trouble concentrating during the day? Are you irritable or moody? If so, you may be suffering from sleep deprivation.

Sleep is essential for our physical, mental, and emotional health. It is the time when our bodies repair and restore themselves, and our brains consolidate memories and process emotions. But despite its importance, many people do not get enough sleep.

Why Do We Lack Sleep?

There are many reasons why people do not get enough sleep. Some common factors include:

    1. Work: Many people work long hours, shift work or work late into the night, which can disrupt their sleep schedules.
    2. Lifestyle: Poor sleep habits, such as staying up late or using electronics in bed, can make it harder to fall asleep.
    3. Medical conditions: Certain medical conditions, such as sleep apnea, restless leg syndrome, or chronic pain, can make it difficult to get a good night's sleep.
    4. Mental health: Anxiety, depression, and other mental health conditions can interfere with sleep.
    5. Medications: Some medications can interfere with sleep, including antidepressants, steroids, and some medications for high blood pressure.
    6. Busy minds. Home life, family, children, dinner, finances - the stresses are great and it’s often hard to shut down for the day.

Causes and Symptoms of Sleep Deprivation

Sleep deprivation occurs when a person does not get enough sleep. It can be acute, meaning it occurs for a short period, or chronic, meaning it occurs over a long period.

The symptoms of sleep deprivation can vary depending on the severity of the condition. Some common symptoms include:

    1. Fatigue
    2. Irritability
    3. Poor concentration
    4. Memory problems
    5. Decreased performance at work or school
    6. Mood changes
    7. Increased risk of accidents or injuries

The Health Effects of Sleep Deprivation

Sleep deprivation can have serious health consequences. Some of the physical, cognitive, and emotional effects of sleep deprivation include:

The Physical Effects of Sleep Deprivation

    1. Increased risk of obesity and diabetes
    2. Weakened immune system
    3. Increased risk of cardiovascular disease
    4. Increased risk of accidents or injuries

The Cognitive Effects of Sleep Deprivation

    1. Impaired cognitive function
    2. Memory problems
    3. Poor concentration
    4. Decreased performance at work or school

The Emotional Effects of Sleep Deprivation

    1. Mood changes
    2. Irritability
    3. Anxiety
    4. Depression

How to Conquer Sleep Deprivation

If you are suffering from sleep deprivation, there are things you can do to improve your sleep. Some tips for better sleep include:

    1. Stick to a consistent sleep schedule: Go to bed and wake up at the same time every day, even on weekends.
    2. Create a relaxing sleep environment: Keep your bedroom cool, quiet, and dark.
    3. Avoid caffeine and alcohol: Both can interfere with sleep.
    4. Avoid electronics in bed: The blue light from electronic devices can disrupt your body's natural sleep cycle. Try reading a book or doing a relaxing activity instead.
    5. Exercise regularly: Regular exercise can improve sleep quality, but avoid exercising too close to bedtime.
    6. Practice relaxation techniques: Techniques such as deep breathing, meditation, or yoga can help you relax and fall asleep more easily.
    7. Establish a bedtime routine: Develop a relaxing bedtime routine to help your body wind down and prepare for sleep.

Tools and Techniques for Better Sleep

In addition to these tips, there are tools and techniques that can help improve your sleep. Some popular options include:

    1. White noise machines: These devices emit a soothing background noise that can help drown out other sounds and help you sleep better.
    2. Sleep tracking apps: These apps can monitor your sleep patterns and provide insights into your sleep habits.
    3. Blue light-blocking glasses: Wearing glasses that block blue light can help reduce the impact of electronic devices on your sleep cycle.
    4. Sleep supplements: Supplements such as adaptogens, melatonin or magnesium can help promote relaxation and improve sleep quality.

When to Seek Professional Help

If you have tried these tips and techniques and are still struggling with sleep deprivation, it may be time to seek professional help. A sleep specialist can help diagnose and treat underlying sleep disorders, such as sleep apnea or insomnia.

In addition, a mental health professional can help address any underlying mental health conditions that may be contributing to your sleep deprivation.

Don't let sleep deprivation take a toll on your health and well-being. Take steps today to improve your sleep habits and conquer sleep deprivation for good.


    1. National Sleep Foundation. (n.d.). Why Do We Need Sleep? Retrieved from https://www.sleepfoundation.org/articles/why-do-we-need-sleep
    2. Centers for Disease Control and Prevention. (2020, March 4). Sleep and Sleep Disorders. Retrieved from https://www.cdc.gov/sleep/index.html
    3. Mayo Clinic. (2021, March 2). Sleep deprivation: A cause of high blood pressure? Retrieved from https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/expert-answers/sleep-deprivation/faq-20057959
    4. Harvard Health Publishing. (2019, December). Sleep and mental health. Retrieved from https://www.health.harvard.edu/newsletter_article/sleep-and-mental-health
    5. American Heart Association. (2021, February 5). How Sleep Deprivation Hurts Your Heart. Retrieved from https://www.heart.org/en/news/2021/02/05/how-sleep-deprivation-hurts-your-heart
    6. National Institute of Neurological Disorders and Stroke. (2021, March 3). Brain Basics: Understanding Sleep. Retrieved from https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Understanding-Sleep
    7. National Sleep Foundation. (n.d.). Sleep and Mood. Retrieved from https://www.sleepfoundation.org/articles/how-sleep-affects-mood
    8. National Sleep Foundation. (n.d.). Sleep Hygiene. Retrieved from https://www.sleepfoundation.org/articles/sleep-hygiene

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Lion’s Mane Mushroom

Lion’s Mane Mushroom

What is Lion's Mane Mushroom?

Lion’s Mane mushroom is also known by the scientific name Hericum erinaceus, and by the common names mountain-priest mushroom and bearded tooth fungus. If a cheerleader named it, it would probably be called pom-pom mushroom.  Its appearance is quite striking.  It grows on hardwoods and can be found in North America, Europe and Asia.   In the United States, they are most commonly found on beech and maple trees in late summer and early fall.  Lion’s Mane mostly feeds on dead trees, which makes it primarily a saprophyte, but it can also be a parasite on living trees, which means that in some cases it gets its nutrients as an endophyte. In Latin, its name means hedgehog, and its German name translates as “hedgehog goatee.” These mushrooms can fruit intermittently on the same dead tree for as long as 20 years.  Although it occurs naturally in the wild in Europe, it is scarce there, leading to protected status in 13 countries and it is illegal to pick or sell in the UK.

What is Lion's Mane Mushroom good for?

Lion’s Mane is a specialty mushroom sometimes used in gourmet cooking.  Its flavor has been described by some as similar to lobster. Lion’s Mane mushroom has been a staple of traditional Chinese medicine for centuries. Lion’s Mane contains polysaccharides such as α-glucan and β-glucan, which can be found in other mushrooms, but also contains species specific compounds called hericenones and erinacenes.

In a broad survey of the potential clinical uses for the compounds occurring in Lion’s Mane, it was found to show activity against some antibiotic-resistant strains of Heliobacter pylori, the bacteria linked to ulcers. It’s ability to inhibit the development of new blood vessels in tumors was demonstrated.

It was shown to combat reduced blood flow and oxygen to the heart muscle (ischemia).  It has been shown to reduce memory impairment and have neuroprotective properties in animal studies, and enhance nerve regeneration.  Animal studies have shown that Lion’s Mane reduced blood glucose and increased insulin.

How does Lion’s Mane Mushroom help my immune system and promote healthy sleep?

Lion's mane mushroom polysaccharides and H. erinaceus extracts have demonstrated immune-enhancing effects in test tube studies.  In other studies, immune function has been theorized to increase by Lion’s Mane activation of macrophages, which are large, specialized cells within the body that detect and destroy other cells within the body that aren’t healthy, such as bacteria, cells infected with a virus, or cells that are mutated into cancerous or pre-cancerous states.  This in turn results in an increase in the release of cytokines and interleukins, proteins that signal the immune system into increased action. It is also believed that Lion’s Mane acts to regulate the balance of healthy gut bacteria, which is also essential to the immune system.

Lion’s Mane has been shown in stress testing of mice to have anti-depressant effects by decreasing levels of neurotransmitters, thus reducing stress. It also resulted in decreased wakefulness in a study of behavioral rhythms in mice.

Who should not take Lion's Mane Mushroom?

Lion’s Mane is a fungus, and that means that people with mushroom or mold allergies should not use it as a dietary supplement. Although Lion’s Mane mushroom is generally well-tolerated, there are no human studies examining its safety or correct dosage.

Tree of Life Botanicals Products with Lion's Mane:

TOLB Immunity

TOLB Sleep


1 Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (lion's mane) mushroom fruiting bodies and mycelia and their bioactive compounds; J Agric Food Chem. 2015;63(32):7108-7123.26244378, M. Friedman.

2 Immunomodulatory effects of hydroxyethylated Hericium erinaceus polysaccharide on macrophages RAW264.7. Int J Biol Macromol. 2017;105 (pt 1):879-885.28729219, Z Ren, T Qin, F Qiu, et al.

3 Immunomodulatory activities of a fungal protein extracted from Hericium erinaceus through regulating the gut microbiota; Front Immunol. 2017;8:666.28713364,  C Diling, Z Chaoqun, Y Jian, et al.

4  https://pubmed.ncbi.nlm.nih.gov/28713364/  Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota; Front Immunol 2017 Jun 12;8:666, Chen Diling, Zheng Chaoqun, Yang Jian, Li Jian, Su Jiyan, Xie Yizhen, Lai Guoxiao.

5 Erinacine A-enriched Hericium erinaceus Mycelium produces antidepressant-like effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice; Int J Mol Sci. 2018;19(2).29364170, CH Chiu, CC Chyau, CC Chen, et al.

6  Hericium erinaceus extracts alter behavioral rhythm in mice; Biomed Res. 2016;37(4):227-232.27544998, S Furuta, R Kuwahara, E Hiraki, K Ohnuki, S Yasuo, K Shimizu.

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Chaga Mushroom

Chaga Mushroom

What is Chaga Mushroom?

Okay, the humble Chaga mushroom is not quite as visually stunning as turkey tail. In fact, it’s downright homely -- but let’s not judge this mushroom by its appearance. Known by the scientific name Inonotus obliquus, this fungus grows on the bark of birch trees in cold climates. It can be found in Alaska, Northern Canada, Northern Europe, Russia, Siberia, and Korea. It is also called black mass, cinder conk, and birch canker.

It grows into a woody mass about one foot across, with a very dark outward appearance similar to a clump of burnt coal. Inside is a soft, vibrant orange core.

What is Chaga Mushroom good for?

Animal studies have linked Chaga mushroom to reduced blood sugar levels. A study in obese, diabetic mice showed that Chaga mushroom extract both reduced blood sugar and insulin resistance compared to a control group that did not receive the supplement.1

Chaga extract may also help to reduce “bad” LDL cholesterol, which in turn reduces the risk of heart disease. The results of animal studies showed that in addition to reducing LDL cholesterol, Chaga increases “good” HDL cholesterol, reduces total cholesterol and triglycerides, and increases antioxidant levels.2

How does Chaga Mushroom help my immune system and promote healthy sleep?

In the short term, inflammation is a natural response of an active immune system. Long-term or chronic inflammation is linked to heart disease, arthritis, IBS, and other digestive tract illnesses, which in turn adversely affect overall health. Animal studies suggest that Chaga mushroom improve the immune system by reducing chronic inflammation and fighting harmful bacteria and viruses.

The way this works is that Chaga compounds promote the formation of specialized proteins called cytokines which regulate the immune system. This stimulates the production of white blood cells. These white blood cells fight viruses and harmful bacteria.3 The upshot is that Chaga mushroom could help fight infections ranging from the common cold to serious illnesses caused by bacteria or viruses.

There may be another pathway for Chaga to help the immune system, in that in addition to promoting the production of good cytokines, Chaga may also inhibit the production of harmful cytokines, the ones that trigger inflammation and are associated with disease.4

Regarding the beneficial effect of Chaga mushroom on sleep, animal studies suggest that Chaga improves sleep by increasing the amount of slow-wave during a sleep cycle.5 Slow-wave sleep is the deepest stage of sleep and is essential for physical recovery and repair. These studies also show that participants show less anxiety-related behavior after taking the Chaga extract.6

Who should not take Chaga Mushroom?

Chaga is a fungus, and that means that people with mushroom or mold allergies should not use it as a dietary supplement. Because Chaga also contains a protein that can prevent blood clotting, if you are on blood-thinning medications, have a bleeding disorder or are preparing for surgery, consult with your doctor before taking Chaga.

Chaga’s impact on blood sugar should be considered as a risk for those taking insulin or those with diabetes. Because there is no research on the safety of chaga for women who are pregnant or breastfeeding, the safest option for those women is to avoid use.

Tree of Life Botanicals Products with Chaga:

TOLB Immunity


1 https://pubmed.ncbi.nlm.nih.gov/18434051/ Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice; J Ethnopharmacol. 2008 Jun 19;118(1):7-13. doi: 10.1016/j.jep.2008.02.030.

2 https://ieeexplore.ieee.org/document/5305591 Effect of the Inonotus Obliquus Polysaccharides on Blood Lipid Metabolism and Oxidative Stress of Rats Fed High-Fat Diet In Vivo; Liya Liang; Zesheng Zhang; Wei Sun; Yuben Wang; Published in: 2009 2nd International Conference on Biomedical Engineering and Informatics

3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774877/ Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus; Mycobiology. 2005 Sep; 33(3): 158–162. Yeon-Ran Kim.

4 https://www.hindawi.com/journals/bmri/2010/943516/ Anti-Inflammatory Effects of Inonotus obliquus in Colitis Induced by Dextran Sodium Sulfate; BioMed Research International, Volume 2010 | Article ID 943516, Se Young Choi, Sun Jin Hur, Chi Sun An, Yun Hui Jeon, Young Jun Jeoung, Jong Phil Bak, and Beong Ou Lim.

5 Baik, H. M., Kim, K. H., & Joh, E. H. (2018). The effect of Chaga mushroom (Inonotus obliquus) extract on sleep, anxiety-related behaviors, and memory in rats. Journal of medicinal food, 21(11), 1000-10014.

6 Kimura, Y., Inatomi, S., & Liu, J. H. (2009). Chloroform extract of Inonotus obliquus improves sleep quality in rats. Biological & pharmaceutical bulletin, 32(12), 225-229.

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What is Melatonin?

You may have noticed that instead of a photograph of a fungus, we have a diagram of the anatomy of the human brain here.  A photo might have been a bit too much.   Melatonin doesn’t come from a fungus, it’s a hormone, and it is produced naturally in the human body by a tiny, pea-sized gland just above the middle of the brain called the pineal gland.  Fortunately, it can also be found in plants and synthesized outside the human body.  It can be found in tart cherries, bananas, plums, grapes, rice, cereals, herbs, and olive oil.

Legally, it is an uncontrolled substance, and is freely available to be purchased as a dietary supplement with no restrictions of any kind, and no need for a prescription.

The function of melatonin in the human body is to regulate sleep.  Normally, our bodies make more melatonin at night, with levels increasing after sunset.  Levels drop in the morning after sunrise.  The amount of light you get each day helps to set your “body clock”, and this determines how much melatonin your body makes.

What is Melatonin good for?

Supplementing the melatonin your body makes is useful for trouble falling asleep or staying asleep.  If you have a job that disrupts normal day/night sleep schedules, or otherwise have difficulty going to sleep at a time that would allow you to get a full sleep cycle, melatonin can be useful.  Melatonin is also helpful if travel to different time zones interferes with your “body clock,” in other words jet lag.

How does Melatonin promote healthy sleep?

Chemically, melatonin is also known as N-Acetyl-5-methoxytryptamine.

Our eyes are the pathway for light, and when we see sunlight, the electrical signals travel through the optic nerves and signal the pineal gland within the brain to stop producing melatonin.  When the eyes do not receive light, melatonin is produced by the pineal gland, and we become sleepy.  This is one of the reasons that eye masks are also an effective sleep aid – in addition to blocking out visual stimuli, they have a physiological effect on the pineal gland.

The physical effects of melatonin, as subjectively reported by those taking it, typically include sedation and very mild muscle relaxation.   Cognitively, users report sleepiness, reduced anxiety, and dream potentiation, meaning that they experiencing experience more dreams, longer dreams, and more vivid dreams.

A systematic review of the medical literature on the effectiveness of melatonin for in promoting healthy sleep was conducted in 2014.  The result of this survey was the observation that although the study quality was generally high in terms of the rigor of the scientific method applied, these studies generally resulted in what the reviewers deemed weak recommendations were for using melatonin in preventing sleep phase shifts from jet lag, for improving insomnia in both healthy volunteers and individuals with a history of insomnia, and for initiating sleep and/or improving sleep efficacy.

Of note, melatonin is also being studied to see if it is helpful in the treatment of Alzheimer’s disease, cancer, ALS (amyotrophic lateral sclerosis), and sleep problems in children with autism disorders.

Who should not take Melatonin?

There has been a lack of research on the safety of melatonin supplements in pregnant or breastfeeding women, so the safest option for those women is to avoid use..  The American Academy of Sleep Sciences recommended against the use of melatonin by people with dementia.  Melatonin may stay active in the body longer in older people and cause daytime drowsiness.

For children, the National Institutes of Health have stated that melatonin supplements at normal doses appear to be safe, but notes that there aren’t many studies on children and melatonin.

Tree of Life Botanicals Products with Melatonin:

TOLB Sleep


1 Salehi B (5 July 2019). "Melatonin in Medicinal and Food Plants" (PDF). Cells. 681.

2 Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders; Sleep Medicine Reviews. 2017;34:10-22, Auld F, Maschauer EL, Morrison I, et al.

3 The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature; Nutr J. 2014; 13: 106, Rebecca B Costello, Cynthia V Lentino, Courtney C Boyd, Meghan L O’Connell, Cindy C Crawford, Meredith L Sprengel, and Patricia.

4 Melatonin: What You Need To Know; NIH National Center for Complementary and Integrative Health; D. Craig Hopp, Ph.D., and David Shurtleff, Ph.D., NCCIH, reviewers. https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know

5 Pharmacologic treatments for sleep disorders in children: a systematic review; Journal of Child Neurology. 2019;34(5):237-247, McDonagh MS, Holmes R, Hsu F.

6 Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An update for 2015; Journal of Clinical Sleep Medicine. 2015;11(10):1199-1236, Auger RR, Burgess HJ, Emens JS, et al
7 Potential safety issues in the use of the hormone melatonin in pediatrics; Journal of Paediatrics and Child Health. 2015;51(6):584-589, Kennaway D.

8 Melatonin in Patients with Reduced REM Sleep Duration: Two Randomized Controlled Trials. https://academic.oup.com/jcem/article/89/1/128/2840303

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Cordyceps Mushroom

Cordyceps Mushroom

What is Coryceps Mushroom?

Cordyceps is a genus of about 600 species of fungus.  Most Cordyceps species are parasites that grow inside insects and other arthropods.  Although prized in ancient Chinese medicine, these insect-dwelling species, such as Cordyceps sinensis, are prohibitively expensive to produce and process, costing as much as $20,000 per kilogram.

Fortunately, some species of Cordyceps, including Cordyceps militaris, are parasitic on other fungi.  These are the Cordyceps found in commercially available supplements, and they contain as much as 90 times the amount of the beneficial compound cordycepin (3’-deoxyadenosine) when compared to Cordyceps sinensis.

Of note, as of 2007, Cordyceps sinensis (also called the caterpillar fungus) was found to be unrelated to most of the rest of the members of the genus, and was renamed Ophiocordyceps sinensis.

Cordyceps are found worldwide, and the largest number of species are concentrated in Asia, notably Nepal, China, Japan, Korea, Viet Nam, and Thailand.  These mushrooms thrive in humid temperate and tropical jungles.

What is Cordyceps Mushroom good for?

Cordyceps is thought to increase the production of adenosine triphosphate (ATP), a molecule essential for delivering nutrition to muscles.  The net effect is that Cordyceps may improve the way your body uses oxygen, especially during exercise, thus boosting exercise performance.

Historically, in Asian herbal medicine Cordyceps has been used by elderly patients to reduce fatigue, and boost strength and sex drive.  It has been considered an anti-aging supplement.  Several animal studies have found that Cordyceps increases antioxidants in aging mice, helping to improve memory and sexual function.

Cordyceps has shown the potential to slow tumor growth in animal studies, and in test-tube studies involving many types of human cancer cells, including human NSC lung cancer, colorectal cancer, and liver cancer.  Researchers believe that these anti-tumor effects may occur in several different ways.

In animal studies Cordyceps has been observed to have an effect that resembles the action of insulin, leading to decreased blood sugar levels.

The effects of Cordyceps on heart health are becoming more evident as research emerges.  Cordyceps is already approved in China for treatment of arrhythmia, or irregular heartbeat.  An animal study showed that Cordyceps significantly reduced heart injuries in rats with chronic kidney disease.  This effect was attributed to the heart-protective properties of the adenosine found in Cordyceps.

How does Cordyceps Mushroom help my immune system and promote healthy sleep?

Cordyceps may also reverse the side effects of many forms of traditional cancer therapy, including leukopenia, a condition in which the number of white blood cells decreases, lowering the body’s immune defenses and increasing the risk of infection.

Fighting inflammation is another area where Cordyceps has been shown to be beneficial.  It is believed that Cordyceps acts as an immunomodulator – a compound that modifies the functioning of the immune system – by suppressing special proteins that increase inflammation.

As a sleep aid, Cordyceps acts through its signature compound, Cordycepin, also known as 3’-deoxyadenosine.  Cordycepin is one of the most bioactive components found in Cordyceps.  It has been shown in animal studies to enhance sleep by increasing non-REM sleep by acting through the adenosine receptors in the central nervous system.

Who should not take Cordyceps?

Cordyceps is a fungus, and that means that people with mushroom or mold allergies should not use it as a dietary supplement.  Because there is no research on the safety of chaga for women who are pregnant or breastfeeding, the safest option for those women is to avoid use.

Always ask a doctor before taking any supplements.  Supplements can have harmful side effects or interactions with other medications.     Cordyceps mushroom may be a promising natural treatment in conjunction with other therapies, and confirming its benefits will require further human research.

Tree of Life Botanicals Products with Cordyceps:

TOLB Immunity

TOLB Sleep


1 https://pubmed.ncbi.nlm.nih.gov/28094746/ Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming; Int J Med Mushrooms 2016;18(12):1083-1092. Yan-Feng Xu

2 https://pubmed.ncbi.nlm.nih.gov/18803231/ Antiaging effect of Cordyceps sinensis extract; Phytother Res. 2009 Jan;23(1):116-22, Deng-Bo Ji, Jia Ye, Chang-Ling Li, Yu-Hua Wang, Jiong Zhao, Shao-Qing Cai.

3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519550/ Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice; J Diabetes Res. 2015; 2015: 723190, Sung-Hsun Yu, Szu-Yu Tina Chen, Wei-Shan Li, Navneet Kumar Dubey, Wei-Hong Chen, Jiunn-Jye Chuu, Sy-Jye Leu, and Win-Ping Deng.

4 https://pubmed.ncbi.nlm.nih.gov/23192916/ Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors; Phytother Res
. 2013 Nov;27(11):1597-604, Xiao-Feng Yan, Zhong-Miao Zhang, Hong-Yi Yao, Yan Guan, Jian-Ping Zhu, Lin-Hui Zhang, Yong-Liang Jia, Ru-Wei Wang.

5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775070/ Cordyceps sinensis Health Supplement Enhances Recovery from Taxol-Induced Leukopenia; Exp Biol Med (Maywood). 2008 Apr; 233(4): 447–455, Wei-Chung Liu, Wei-Ling Chuang, Min-Lung Tsai, Ji-Hong Hong, William H. McBride, and Chi-Shiun Chiang.

6  https://pubmed.ncbi.nlm.nih.gov/8874668/ Cordyceps sinensis as an immunomodulatory agent; Am J Chin Med. 1996;24(2):111-25, Y C Kuo, W J Tsai, M S Shiao, C F Chen, C Y Lin.

7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371127/ Anti-inflammatory effects of Cordyceps mycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages; Orient Pharm Exp Med. 2015; 15(1): 7–12, Seong-Yeol Park,1 Su-Jin Jung,2 Ki-Chan Ha,3 Hong-Sig Sin,4 Seung-Hwan Jang,4 Han-Jung Chae,5 and Soo-Wan Chae.
8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655593/ Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats; Evid Based Complement Alternat Med. 2013; 2013: 840134, Zhenzhen Hu, Chung-Il Lee, Vikash Kumar Shah, Eun-Hye Oh, Jin-Yi Han, Jae-Ryong Bae, Kinam Lee, Myong-Soo Chong, Jin Tae Hong, and Ki-Wan Oh.
9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437265/ Bidirectional regulatory effects of Cordyceps on arrhythmia: Clinical evaluations and network pharmacology.

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Turkey Tail Mushroom

Turkey Tail Mushroom

What is Turkey Tail Mushroom?

First, it is hard to ignore just how strikingly beautiful Turkey Tail mushrooms are.  The common name derives from the banded appearance of a wild turkey’s tail when fanned out in full display.  The species is known by several scientific names, including Coriolus versicolor, Trametes versicolor, and Polyporus versicolor.

These mushrooms grow in tiled layers or in groups or rows on fallen logs and stumps of deciduous trees in heavily wooded areas.  The mushroom is all fruiting body, there is no stalk.  They are plentiful in various parts of the world, including the United States.

As a raw mushroom, Turkey Tail is considered inedible due to its leathery, chewy texture, which makes it virtually impossible to chew and swallow. In addition, Turkey Tail has a strong, earthy flavor.  It is typically consumed as a powder, tea, or extract.

In ancient Japanese culture Turkey Tail was called the “cloud mushroom” and its use is said to date back to the Han Dynasty in 200 B.C.  In Chinese herbal medicine Turkey Tail mushroom has long been used to fight infections and support immune function.

What is Turkey Tail mushroom good for?

Turkey Tail mushrooms really pack a punch in the arena of nutritional benefits.  They are loaded with antioxidants which reduce what is known as “oxidative stress.”  Oxidative stress is a cause of cell damage and chronic inflammation, which can lead to cancer and heart disease.  Eating foods rich in antioxidants, like Turkey Tail, can decrease your chance of illness.

The compounds found in Turkey Tail are also known to promote gut health.  Having a healthy colony of bacteria in the gut is vital to overall health.  Turkey Tail mushroom may help keep the right balance of gut bacteria.  The compounds and fiber found in Turkey Tail have prebiotic abilities that help the gut regulate that balance.  Prebiotics are a specific type of fiber that act as a food source for healthy bacteria in the gut.

A healthy gut means that the body can more readily absorb key nutrients such as vitamin B12 and vitamin D, reducing the risk and severity of digestive illnesses such as IBS, colitis, and Crohn's disease. In addition, gut health helps to increase overall energy, moderate glucose metabolism, and promote healthy weight loss, all of which can help prevent or reduce the severity of diabetes.

There is limited research suggesting a compound found in Turkey Tail mushrooms called Protein-bound Beta-Glucan (PBG) can help prevent obesity.  PBG has been found to help prevent weight gain in mice that ate a high fat diet.

How does Turkey Tail Mushroom help my immune system?

Turkey tail mushroom contains two beneficial compounds called Polysaccharide-K, also known as PSK or krestin, and Polysaccharopeptide, also known as PSP.  In Japan, PSK is considered safe and approved for clinical use as an adjuvant therapy for cancer.  That means it is given in addition to primary or initial cancer therapy to maximize its effectiveness.

PSP and PSK have been studied in clinical research in people with various cancers and immune deficiencies

These compounds appear to inhibit the growth of cancer cells, and some evidence suggests that PSP may also have the ability to stimulate the immune system, especially when combined with other cancer treatments.  In summary, medical research of the effects of PSP has been focused on cytokine release, especially on the potential of PSP to activate natural killer (NK) cells.

Who should not take Turkey Tail mushroom?

Turkey Tail is a fungus, meaning people with mushroom or mold allergies should not use it as a dietary supplement.  Although research has not identified other severe side effects associated with turkey tail, milder side effects could include heartburn, constipation, nausea, chest pain, or symptoms that are similar to having a cold or the flu.

Although Turkey Tail mushroom extracts have been studied and found useful alongside traditional cancer therapy, Turkey Tail mushroom is not a cancer treatment by itself, or an approved cancer medicine in the United States. Because there is no research on the safety of Turkey Tail for women who are pregnant or breastfeeding, the safest option for those women is to avoid use.

Tree of Life Botanicals Products with Turkey Tail:

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1 "Turkey tail and polysaccharide-K. In: Medicinal Mushrooms". National Cancer Institute, US National Institutes of Health. 5 October 2020. Retrieved 10 February 2021.

Huaiqian Dou; others (2019). Glycans and glycosaminoglycans as clinical biomarkers and therapeutics - Part B. In: Progress in Molecular Biology and Translational Science, Trametes versicolor - an overview : Ed.: Lijuan Zhang. Vol. 163. Elsevier Inc. pp. 1–533. Retrieved 10 February 2021.

"Turkey tail". Drugs.com. 21 October 2020. Retrieved 10 February 2021.

"Coriolus versicolor". Memorial Sloan Kettering Cancer Center, New York, NY. 2021. Retrieved 8 February 2021.

Habtemariam, S (25 May 2020). "Trametes versicolor (Synn. Coriolus versicolor). Polysaccharides in cancer therapy: targets and efficacy". Biomedicines. 8 (5): 135. doi:10.3390/biomedicines8050135. ISSN 2227-9059. PMC 7277906. PMID 32466253.

2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592279/ Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide Mohammad H. Saleh,1,2,† Iran Rashedi,2 and Armand Keating1,2,*

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Shiitake Mushroom

Shiitake Mushroom

What is Shiitake Mushroom?

This wonderful fungus is native to East Asia but is now grown and consumed around the world.  Its current binomial (genus and species) taxonomic designation is Lentinula edodes. An interesting bit of trivia is that it went through 12 different scientific names between 1878 and 1941.  The Japanese name, Shiitake, comes from “shii”, for the tree that provides the dead logs it is typically grown on in Japan, and “take”, which is mushroom in Japanese.  The Latin species name, edodes, means edible.

It also commonly known as black forest mushroom, golden oak mushroom, or oakwood mushroom.  Shiitake grows in groups on deciduous trees like oak, chestnut, maple, beech, poplar, and mulberry, which is one of the reasons why it can be successfully cultivated worldwide.  Its worldwide distribution, however, is a relatively new development, beginning with a 1982 article in a forest products journal.

Shiitake now account for fully 25% of the mushrooms cultivated worldwide.

What is it good for, and can Shiitake Mushroom help my immune system?

Shiitake mushroom has been studied to see if it improves human immune function.  One study determined that consuming Shiitake for four weeks increased the proliferation of killer T-cells, improved gut immunity, decreased inflammation, and increased interleukin and tumor necrosis factor levels.

In an animal study, researchers found that Shiitake mushroom rejuvenated the immunity and gut microbiomes in aging mice.  This effect was thought to be the result of the polysaccharides found in Shiitake reversing the age-altered composition of the bacteria within the gut by increasing cytokine levels in the bloodstream.

Shiitake mushrooms are also thought to improve heart health.  They contain eritadenine, sterols, and beta glucans, all of which have a direct effect on cholesterol, lowering it by either inhibiting its production in the body, or blocking its absorption in the gut.

The polysaccharides in Shiitake mushrooms are also believed to have anti-cancer effects.   The polysaccharides isolated from Shiitake have been described as “the most potent antitumor and immunomodulating substance” in this species.  Specifically, the polysaccharide lentinan, extracted from Shiitake, has been shown to inhibit the spread of leukemia cells.   In China and Japan, refined lentinan is used alongside chemotherapy to improve immune function in cancer patients.

Scientists have also noted that several compounds found in Shiitake fight bacterial, viral, and fungal infections. In addition to improving immune function, these compounds also have antimicrobial properties, attacking and suppressing these pathogens directly.

Who should not take Shiitake?

Shiitake is a fungus, and that means that people with mushroom or mold allergies should not use it as a dietary supplement. Because there is no research on the safety of Shiitake for women who are pregnant or breastfeeding, the safest option for those women is to avoid use.

Tree of Life Botanicals Products with Shiitake:

TOLB Immunity


1 Cultivation of shiitake, the Japanese forest mushroom, on logs: a potential industry for the United States; Forest Products Journal. 32 (8): 29–35, Leatham, GF.

2 Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults; J Am Coll Nutr. 2015;34(6):478-87, Xiaoshuang Dai, Joy M Stanilka, Cheryl A Rowe, Elizabethe A Esteves, Carmelo Nieves Jr, Samuel J Spaiser, Mary C Christman, Bobbi Langkamp-Henken, Susan S Percival.

3 Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota; Food Funct. 2015 Aug;6(8):2653-63, Xiaofei Xu, Jiguo Yang, Zhengxiang Ning, Xuewu Zhang

4 Vitamin D and sterol composition of 10 types of mushrooms from retail suppliers in the United States; J Agric Food Chem. 2011 Jul 27;59(14):7841-53; Katherine M Phillips, David M Ruggio, Ronald L Horst, Bart Minor, Ryan R Simon, Mary Jo Feeney, William C Byrdwell, David B Haytowitz

5 Determination of Glucan Contents in the Fruiting Bodies and Mycelia of Lentinula edodes Cultivars; Mycobiology. 2014 Sep;42(3):301-4, Won Chull Bak, Ji Heon Park, Young Ae Park, Kang Hyeon Ka

6 Edible mushrooms: Role in the prevention of cardiovascular diseases; Fitoterapia Volume 81, Issue 7, October 2010, Pages 715-72, Eva Guillamón, Ana García-Lafuente, Miguel Lozano, Matilde D´Arrigo, Mauricio A. Rostagno, Ana Villares, José Alfredo Martínez

7 Polysaccharides in Lentinus edodes: isolation, structure, immunomodulating activity and future prospective; Crit Rev Food Sci Nutr. 2014;54(4):474-87, Xiaofei Xu, Huidan Yan, Jian Tang, Jian Chen, Xuewu Zhang

8 Recent developments in mushrooms as anti-cancer therapeutics: a review; 3 Biotech. 2012 Mar; 2(1): 1–15, Seema Patel and Arun Goyal

9 The Pharmacological Potential of Mushrooms; Evid Based Complement Alternat Med. 2005 Sep; 2(3): 285–299, Ulrike Lindequist, Timo H. J. Niedermeyer, and Wolf-Dieter Jülich

10 Mutated Shiitake extracts inhibit melanin-producing neural crest-derived cells in zebrafish embryo. https://pubmed.ncbi.nlm.nih.gov/33737223/

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Reishi Mushroom

Reishi Mushroom

What is Reishi Mushroom?

The scientific name for Reishi mushroom is Ganoderma lingzhi, and it is also known as Lingzhi.  Reishi, from the Japanese pronunciation, is a polypore fungus native to East Asia belonging to the genus Ganoderma. When we say ‘polypore’, whether in botany or mycology, that means that the fungus forms large fruiting bodies with pores or tubes on the underside.  As an analogy, a strawberry is a botanical polypore.   Reishi fruiting bodies appear as reddish-brown, kidney-shaped caps with bands. The stem, extending from a point along the edge, gives it a distinct fan-like appearance. When fresh, Reishi is soft and somewhat cork-like.

Reishi grows at the base and stumps of deciduous trees.  Its favorite host is the maple tree, but it is relatively rare in the wild. It is cultivated for commercial purposes on hardwood logs, woodchips, and even in sawdust.  Reishi is found in East Asia, and it has two close relatives in North America.  Because of its bitter taste, it is usually dried and taken in capsule form, although historically it has been used in Asia as a tea, still quite bitter, but beneficial.  As Mary Poppins might say, a spoon full of sugar helps this medicine go down.

What is Reishi good for, and how does it help my immune system?

First and foremost, Reishi has been shown to boost the immune system.   Studies show that the polysaccharides in Reishi modulate immune function extensively, in several different metabolic pathways, including altering inflammation in white blood cells and increasing natural killer cells.

Reishi has also been shown to improve lymphocyte function in athletes under stress.

Historically, and currently, Reishi is consumed for its anti-cancer properties. It has been a popular herbal cancer chemotherapy agent in traditional Chinese medicine.  Current studies show that the benefits of Reishi included increasing the activity of the body’s white blood cells, which help fight cancer, and improving quality of life in cancer patients.  Nonetheless, researchers concluded that Reishi should be administered in combination with traditional treatment rather than replacing it.

Reishi has also been studied for the reduction of fatigue and depression.  Researchers observed that participants were less fatigued and more well rested and had an enhanced feeling of well-being after taking Reishi supplements for 8 weeks.

Will Reishi mushroom promote healthy sleep?

Yes, in a roundabout but significant way:

Rather than making you drowsy, Reishi influences sleep by measurably reducing stress and increasing calmness.  A study found that three days of Reishi mushroom use “significantly increased total sleep time and non-rapid eye movement sleep” in animal test subjects. Researchers observed an increase in levels of tumor necrosis factor alpha (TNF-a), a key substance in sleep regulation.

Another animal sleep study detailed findings that Reishi extract decreased sleep latency, and increased sleeping time, noting that the test subjects fell asleep faster and slept longer after three days of use. The test subjects also displayed a decreased amount of spontaneous activity, like fidgeting or anxious behaviors.

Who should not take Reishi?

Reishi is a fungus, and that means that people with mushroom or mold allergies should not use it as a dietary supplement.  Because there is no research on the safety of Reishi for women who are pregnant or breastfeeding, the safest option for those women is to avoid use.

Tree of Life Botanicals Products with Reishi:

TOLB Immunity

TOLB Sleep


1 Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum; J Pharmacol Sci. 2005 Oct;99(2):144-53, Zhi-Bin Lin

2 The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells; Nutr Cancer. 2010;62(5):648-58, Chun-Huai Cheng, Albert Y Leung, Chin-Fu Chen

3 Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients; Immunol Invest. 2003 Aug;32(3):201-15, Yihuai Gao, Shufeng Zhou, Wenqi Jiang, Min Huang, Xihu Dai

4 Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low"; Br J Sports Med. 2008 Oct;42(10):819-22, Y Zhang, Z Lin, Y Hu, F Wang

5 Ganoderma lucidum (Reishi) in cancer treatment; Integr Cancer Ther. 2003 Dec;2(4):358-64, Daniel Sliva

6 Ganoderma lucidum (Reishi mushroom) for cancer treatment; Cochrane Database Syst Rev. 2016 Apr 5;4(4), Xingzhong Jin, Julieta Ruiz Beguerie, Daniel Man-Yeun Sze, Godfrey C F Chan

7 A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia; J Med Food. 2005 Spring;8(1):53-8, Wenbo Tang, Yihuai Gao, Guoliang Chen, He Gao, Xihu Dai, Jinxian Ye, Eli Chan, Min Huang, Shufeng Zhou

8 Extract of Ganoderma lucidum prolongs sleep time in rats; J Ethnopharmacol. 2012 Feb 15;139(3):796-800, Xiang-Yu Cui, Su-Ying Cui, Juan Zhang, Zi-Jun Wang, Bin Yu, Zhao-Fu Sheng, Xue-Qiong Zhang, Yong-He Zhang

9 Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism; Pharmacol Biochem Behav. 2007 Apr;86(4):693-8, Qing-Ping Chu, Li-En Wang, Xiang-Yu Cui, Hong-Zheng Fu, Zhi-Bin Lin, Shu-Qian Lin, Yong-He Zhang

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What is Magnesium?

Magnesium is a mineral, like copper or zinc.  Our bodies need a full array of vitamins and minerals to function optimally.  The role of magnesium in the body is to help regulate blood pressure, transmit signals through our nerves, and control our moods.  It also helps us sleep.  Because magnesium is a part of so many different metabolic processes, a deficiency can result in a wide array of disorders.  Magnesium is found naturally in many of the foods we eat, such as leafy green vegetables, legumes, whole grains, seeds and nuts.  Because many of us are faced with menu choices that aren’t composed of whole foods, we find ourselves having to supplement our diets, and fortunately, magnesium is an easy mineral to add to your daily routine.

What is Magnesium good for?

It’s important to note that elemental magnesium is difficult to absorb into the body.  The best way to maximize the absorption of magnesium is to “chelate” it by binding it to an amino acid.  Magnesium can be successfully bound to lysine, citrine, taurine, glycine, or threonine to allow it to be absorbed in the digestive tract.

One of the benefits of chelated magnesium is to relieve constipation.  The mechanism for this is as a muscle relaxant, allowing the digestive system to stop constricting.  Many find that relief occurs overnight while they sleep.  The muscle relaxation effect of magnesium is also how magnesium helps with sleep itself.  Magnesium benefits the parasympathetic nervous system, which helps relieve anxiety and stress, resulting in an easier time falling asleep.

How does Magnesium promote healthy sleep?

Studies have resulted in encouraging findings on the role of magnesium supplements in the treatment of insomnia.  Researchers found that magnesium supplementation helped subjects fall asleep faster, stay asleep longer, reduced nighttime awakenings, and increased their levels of naturally circulating melatonin.  Other studies showing promising results have focused on combining magnesium with other supplements such as melatonin and vitamins.

Another area of study related to sleep has been the use of supplemental magnesium to treat Restless Legs Syndrome.  Restless Leg syndrome Syndrome involves an involuntary urge to move the legs, and the resulting involuntary motion interferes with sleep.  While it is not clear exactly what causes this disorder, some researchers have suggested that magnesium deficiency may play a role in the development of the condition during pregnancy or while receiving dialysis.

Who should not take Magnesium?

In most cases, magnesium supplements are safe. A dangerously high level of magnesium is rare in otherwise healthy people unless they take a very high dose of magnesium.  Symptoms of excessive magnesium range from mild to extreme and include nausea, headache, low blood pressure, muscle paralysis and cardiac arrest.  The risk for toxicity is higher for people who have impaired kidney function, and those who have colitis, gastritis, or gastric ulcer disease.

As a dietary supplement, it may be a useful addition to a medical treatment plan, taken under a doctor’s supervision and with their approval.

Tree of Life Botanicals Products with Magnesium:

TOLB Immunity

TOLB Sleep


1 Oral magnesium supplementation for insomnia in older adults: A systematic review & meta-analysis; BMC Complementary Medicine and Therapies, 21(1), 1-11, Mah, J., & Pitre, T. (2021). https://pubmed.ncbi.nlm.nih.gov/33865376

2 The effects of magnesium–melatonin-vit B complex supplementation in treatment of insomnia; Open Access Macedonian Journal of Medical Sciences, 7(18), 3101, Djokic, G., Vojvodić, P., Korcok, D., Agic, A., Rankovic, A., Djordjevic, V., Vojvodic A.,Vlaskovic-Jovicevic, T., Peric-Hajzler, Z.,Matovic, D., Vojvodic, J., Sijan, G., Wollina, W., Van Thuong, N., Fioranelli, M., & Lotti, T. (2019)

3 Zinc and magnesium levels of pregnant women with restless leg syndrome and their relationship with anxiety: A case-control study; Biological Trace Element Research, 199(5), 1674-1685, Yıldırım, E., & Apaydın, H. (2021)

4 Association between predialysis hypermagnesaemia and morbidity of uraemic restless legs syndrome in maintenance haemodialysis patients: A retrospective observational study in Zhejiang, China; BMJ open, 9(7), e027970, Yang, Y., Ye, H., He, Q., Zhang, X., Yu, B., Yang, J., & Chen, J. (2019)https://pubmed.ncbi.nlm.nih.gov/31292178/

5 Baik, H. M., Kim, K. H., & Joh, E. H. (2018). The effect of Chaga mushroom (Inonotus obliquus) extract on sleep, anxiety-related behaviors, and memory in rats. Journal of medicinal food, 21(11), 1000-10014.

6  Hypermagnesemia: Causes, symptoms, and treatment. In M. Emmett & R. H. Sterns (Eds.); Yu, A. S. (2022, May 19)

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The Health Benefits High Dose CBD – Case Study

Christian Shaw, MD, PhD, Halcyon Therapeutics LLC, Phoenix, Arizona and Jahan Marcu, PhD, Editor in Chief are pioneers in the study of CBD and its many health benefits.

You can download their in depth research paper on Cannabidiol in the Management of Comorbid Rheumatoid Arthritis, Lupus, and Raynaud’s Disease by clicking the image below.

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Not completely satisfied with your purchase? We are so confident that you will be satisfied with our top-quality products that we offer a One Year full money back guarantee*.

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